Combination therapy with bosentan and phosphodiesterase-5 inhibitor in pulmonary arterial hypertension.

therapy to control lung damage in patients with common variable immunodeficiency. Int Immunopharmacol 2004; 6: 745–753. 4 de Gracia J, Morell F, Bofill JM, Rodrigo MJ, Cosculluela C. Impaired lung function in patients with IgA deficiency and low levels of IgG2 or IgG3. N Engl J Med 1986; 314: 925–926. 5 de Gracia J, Miravitlles M, Vendrell M, Rodrigo MJ, Codina R, Morell F. Study of the IgG subclasses in symptomatic patients with IgA deficiency. Med Clin (Barc) 1995; 104: 728–731. 6 Rodrigo MJ, Vendrell M, Cruz MJ, et al. Utility of the antibody response to a conjugated H. influenzae type B vaccine for diagnosis of primary humoral immunodeficiency. Am J Respir Crit Care Med 2000; 162: 1462–1465. 7 Rodrigo MJ, Miravitlles M, Cruz MJ, et al. Characterization of specific immunoglobulin G (IgG) and its subclasses (IgG1 and IgG2) against the 23-valent pneumococcal vaccine in a healthy adult population: proposal for response criteria. Clin Diagn Lab Immunol 1997; 4: 168–172. 8 Vendrell M, de Gracia J, Rodrigo MJ, et al. Antibody production deficiency with normal IgG levels in bronchiectasis of unknown etiology. Chest 2005; 127: 197–204. 9 Ambrosino DM, Siber GR, Chilmonczyk BA, Jernberg JB, Finberg RW. An immunodeficiency characterized by impaired antibody responses to polysaccharides. N Engl J Med 1987; 316: 790–793. 10 de Gracia J, Rodrigo MJ, Morell F, et al. IgG subclass deficiencies associated with bronchiectasis. Am J Respir Crit Care Med 1996; 153: 650–655. 11 Miravitlles M, de Gracia J, Rodrigo MJ, et al. Specific antibody response against the 23-valent pneumococcal vaccine in patients with a1-antitrypsin deficiency with and without bronchiectasis. Chest 1999; 116: 946–952.